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Raymond P Baumann Selected Research

laromustine (VNP40101M)

1/2018pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs.
6/2013Expression of O6-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue.
3/2013Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.
10/2012Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.
3/2012Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors.
11/20114-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
6/2010Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance.
10/2008Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.
1/2005The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.

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Raymond P Baumann Research Topics

Disease

17Neoplasms (Cancer)
01/2021 - 01/2005
7Hypoxia (Hypoxemia)
02/2013 - 11/2008
6Carcinoma (Carcinomatosis)
01/2016 - 11/2008
3Leukemia
01/2016 - 01/2005
2Fanconi Anemia (Fanconi's Anemia)
01/2016 - 03/2012
2Glioma (Gliomas)
05/2011 - 11/2008
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2008 - 01/2005
1Ovarian Epithelial Carcinoma
01/2016

Drug/Important Bio-Agent (IBA)

13ProdrugsIBA
01/2021 - 01/2005
9laromustine (VNP40101M)IBA
01/2018 - 01/2005
9O(6)-Methylguanine-DNA MethyltransferaseIBA
05/2015 - 06/2010
7DNA (Deoxyribonucleic Acid)IBA
01/2016 - 10/2008
6Oxygen (Dioxygen)IBA
08/2012 - 11/2008
5Proteins (Proteins, Gene)FDA Link
05/2015 - 11/2011
5hydrazine (hydrazine dihydrochloride)IBA
11/2011 - 01/2005
4GuanineIBA
06/2013 - 11/2010
3Antineoplastic Agents (Antineoplastics)IBA
01/2016 - 02/2013
3Carmustine (FIVB)FDA Link
08/2014 - 11/2010
3Temozolomide (Temodar)FDA LinkGeneric
06/2013 - 11/2010
3O(6)-benzylguanineIBA
02/2013 - 11/2011
3EnzymesIBA
11/2011 - 11/2008
31,2- bis(methylsulfonyl)- 1- - (2- chloroethyl)- 2- ((1- (4- nitrophenyl)ethoxy)carbonyl)hydrazineIBA
10/2011 - 11/2008
2Alkylating AgentsIBA
06/2013 - 11/2010
2Alkyl and Aryl TransferasesIBA
02/2013 - 10/2012
2Oxidoreductases (Dehydrogenase)IBA
11/2011 - 05/2011
1Paclitaxel (Taxol)FDA LinkGeneric
01/2016
1Carboplatin (JM8)FDA LinkGeneric
01/2016
1Cisplatin (Platino)FDA LinkGeneric
01/2016
1PlatinumIBA
01/2016
13-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA
01/2016
1RNA (Ribonucleic Acid)IBA
01/2016
1Mitomycin (Mitomycin-C)FDA LinkGeneric
01/2016
1IsoenzymesIBA
08/2014
1MethyltransferasesIBA
06/2013
1Superoxides (Superoxide)IBA
10/2012
17-nitro-4-(phenylthio)benzofurazanIBA
10/2012
1Pharmaceutical PreparationsIBA
10/2012
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
10/2012
1DNA alkyltransferaseIBA
08/2012
1TransferasesIBA
03/2012
1Cytotoxins (Cytolysins)IBA
10/2011
1AnnexinsIBA
01/2005
1methyl isocyanateIBA
01/2005

Therapy/Procedure

1Drug Therapy (Chemotherapy)
01/2016
1Radiotherapy
03/2012